Cibiyar 'Yancin Falasdinu ta kafa Cibiyar Kimiyya da Fasaha ta Falasdinu a shekara ta 1994 bisa bukatar UNESCO. An kafa ta a hukumance ta Dokar Shugaban kasa mai lamba 114 a shekarar 1997, inda ta amince da matsayinta a matsayin kungiya mai cin gashin kanta, mai zaman kanta, kuma ba ta riba ba. Wannan doka ta ba wa Kwalejin damar yin aiki a matsayin cibiyar farko na kimiyya da fasaha a cikin ƙasa, wanda aka ba da shawara kan tsara manufofi, shirye-shirye, da ayyuka don tallafawa ci gaban ƙasa, da daidaita ayyukan kimiyya da fasaha (S&T) masu dacewa. Sakamakon haka, Cibiyar ta zama cibiyar cibiyar kimiyya da fasaha a Falasdinu.
Dr. Fathi Arafat ya aka nada a matsayin shugabanta na farko, tare da HE Yasser Arafat, shugaban hukumar mulkin Falasdinawa, wanda ke aiki a matsayin shugaban kasa mai daraja.
A cikin 1998, an nada Dr. Rafiq Al-Husseini a matsayin Babban Sakatare na farko na Kwalejin. Dr. Mohamed Ziara ya gaje shi a matsayin babban sakataren riko a shekara ta 2000, sai kuma Dakta Imad Al-Khatib a farkon shekara ta 2001, wanda da farko ya rike mukamin mukaddashin babban sakataren kafin a nada shi babban sakataren a karshen shekarar. An nada Dakta Hikmat Ajjuri mataimakiyar shugabar makarantar.
An sake tabbatar da matsayin Kwalejin Dokar Shugaban Kasa mai lamba 13 a shekarar 2004 (a Turanci) , ya kara kafa ta a matsayin cibiyar kasa, mai zaman kanta, mai cin gashin kanta. Kwalejin Kimiyya da Fasaha ta Falasdinu tana taka muhimmiyar rawa wajen inganta kimiyya, fasaha, da kirkire-kirkire a cikin Falasdinu tare da ba da damar yin amfani da su a matsayin masu tafiyar da tattalin arziki, zamantakewa, da ci gaban bil'adama. Don cimma wannan, Kwalejin tana aiki tare da abokan haɗin gwiwa daga masana kimiyya, gwamnati, da masana'antu, na gida da na duniya. Haɗin kai da inganta ƙoƙarin ƙasa yana da mahimmanci musamman idan aka yi la'akari da ƙarancin albarkatun da kuma manyan ƙalubalen da ake fuskanta. Cibiyar Kwalejin tana da hedikwata a Kudus, tare da ƙarin ofisoshi a Ramallah da Gaza.
